Human Cell Atlas-Asia (HCA-Asia) was formed in 2017 to create a coordinated platform for researchers based in Asia to collaborate, share data and plan future initiatives for the HCA. Our goals and framework are broadly aligned with those of the global HCA community. We aim to create comprehensive reference maps of all human cells in Asia as a basis for both understanding human health, as well as diagnosing, monitoring, and treating disease.
This year, the Genome Institute of Singapore (GIS) is delighted to organise the third annual HCA-Asia Meeting, which takes place from 10 – 11 November 2019 at Matrix, Biopolis, Singapore. During this meeting, we will address scientific and logistical issues in working across national boundaries to contribute to the HCA Data Coordination Platform. We will also formally incorporate the Equity and Ethics goals of the HCA. The meeting comprises both scientific seminars and workshop-style discussions on HCA-Asia collaborative programmes and funding mechanisms.
In London on 13 and 14 October, 2016, a collaborative community of world-leading scientists met and discussed how to build a Human Cell Atlas — a collection of maps that will describe and define the cellular basis of health and disease.
Cells are the most fundamental unit of life, yet we know surprisingly little about them. They vary enormously within the body, and express different sets of genes. Without maps of different cell types and where they are located in the body, we cannot describe all their functions and understand the biological networks that direct their activities.
A complete Human Cell Atlas would give us a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues, knowledge of how all body systems are connected, and insights into how changes in the map underlie health and disease. It would allow us to identify which genes associated with disease are active in our bodies and where, and analyze the regulatory mechanisms that govern the production of different cell types.
This has been a key challenge in biology for more than 150 years. New tools such as single-cell genomics have put it within reach. It is an ambitious but achievable goal, and requires an international community of biologists, clinicians, technologists, physicists, computational scientists, software engineers, and mathematicians.
A White Paper, openly available for download, provides an overview of the effort; our framework for the first draft of the atlas; descriptions of the technology and data analysis tools available to build the atlas; an introduction to the Data Coordination Platform that will host the data for researchers worldwide; a deeper look at biological systems we plan to explore and map; and details on the organization and governance of the HCA consortium and its relationships to the public (including ethical considerations regarding organ and tissue donors) and to funding support.
For more information about the Human Cell Atlas, visit https://www.humancellatlas.org.
The Genome Institute of Singapore (GIS) is an institute of the Agency for Science, Technology and Research (A*STAR). It has a global vision that seeks to use genomic sciences to achieve extraordinary improvements in human health and public prosperity. Established in 2000 as a centre for genomic discovery, the GIS will pursue the integration of technology, genetics and biology towards academic, economic and societal impact.
The key research areas at the GIS include Human Genetics, Infectious Diseases, Cancer Therapeutics and Stratified Oncology, Stem Cell and Regenerative Biology, Cancer Stem Cell Biology, Computational and Systems Biology, and Translational Research.
The genomics infrastructure at the GIS is utilised to train new scientific talent, to function as a bridge for academic and industrial research, and to explore scientific questions of high impact.
For more information about GIS, please visit https://www.a-star.edu.sg/gis
The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that spearheads economic oriented research to advance scientific discovery and develop innovative technology. Through open innovation, we collaborate with our partners in both the public and private sectors to benefit society.
As a Science and Technology Organisation, A*STAR bridges the gap between academia and industry. Our research creates economic growth and jobs for Singapore, and enhances lives by contributing to societal benefits such as improving outcomes in healthcare, urban living, and sustainability.
We play a key role in nurturing and developing a diversity of talent and leaders in our Agency and research entities, the wider research community and industry. A*STAR’s R&D activities span biomedical sciences and physical sciences and engineering, with research entities primarily located in Biopolis and Fusionopolis.
For ongoing news, visit www.a-star.edu.sg.